R&D – Allergen Immunotherapy
Open a new path for allergy diagnosis and therapy
Allergen Immunotherapy
Until now, the main treatment for allergic diseases have been antigen avoidance therapy and drug therapy to block allergic reactions by prescribing antihistamines or steroids. However, these treatments have limitations as they serve to reduce the reaction rather than resolve the cause of allergies.
In contrast, immunotherapy is a method of inducing immune tolerance using allergenic substances. It is a new allergy treatment plan that gradually desensitizes the immune response by regularly administering increasing doses at very low concentrations, essentially preventing allergic reactions from occurring. Widely known immunotherapy include sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT), but all allergens used here are currently imported from overseas, and the administration method also has the inconvenience of having to visit hospitals and clinics periodically for treatment.
Prolagen Co., Ltd. is being developed Immunotherapy using microarray patches, its advantages more highlighted when compared to the currently used immunotherapy method, SCIT. The biggest advantage is that the same effect can be achieved with a small amount of allergen, and treatment can be performed at a nearby medical institution or at home, making treatment more convenient and safe.
| Division | Subcutaneous injection (SCIT) | Microarray patch (MAPT) |
| Route of administration |
· Muscle layer administration · Rapid injection of antigen (allergen) · Professional medical staff · Allergy Specialist Clinic |
· Dermal layer administration(rich in immune cells) · Slowly dissolves in the dermal layer · Easy self-attachment · Local clinic |
| Storage |
· Refrigerated storage, distribution |
· Room temperature Storage |
Microarray Patch (MAP)
Soluble microarray patches, also called “painless injections”, are a type of transdermal delivery system that delivers drugs efficiently by penetrating the skin with a needle as thin as a mosquito’s proboscis. This new concept of drug delivery system eliminates pain, trauma, infection, fear, and repulsion, which are the main disadvantages of conventional syringes.
Since this delivery system does not involve passing a drug through the gastrointestinal tract, it can be administered irrespective of pH, enzymes, foods, or gastrointestinal tract movements that affect drug absorption. It has other advantages of being simple to use and enabling long-term, continuous administration as well as easy control of blood concentration.
